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Current Issue
Volume 134,
Issue 23,
December 5, 2019

Issue Highlights

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2019 Blood Cover Art Contest

Blood is celebrating the extraordinary visual impact of the Blood art images by launching its third annual Cover Art Contest. The voting for this contest is based on visual impact only, not scientific or technical merit.

See all of the eligible covers and VOTE for your favorite cover, today!

Featured Content


MELK mediates the stability of EZH2 through site-specific phosphorylation in extranodal natural killer/T-cell lymphoma

This article describes the interplay between the serine/threonine kinase maternal embryonic leucine zipper kinase (MELK) and the enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2) and provides a basis for targeting this enzymatic pathway in mature natural killer/T-cell malignancies.


Germline mutations in the transcription factor IKZF5 cause thrombocytopenia

The authors provide evidence of a novel association between transcription factor IKZF5, one of the IKAROS family proteins, and thrombocytopenia with decreased alpha granules, thus significantly extending our understanding of the gene defects leading to inherited thrombocytopenia.


Diagnostic high-throughput sequencing of 2396 patients with bleeding, thrombotic, and platelet disorders 

This paper reports on the use of a high-throughput diagnostic genetic screening for coagulation, platelet, or thrombotic disorders in a series of more than 2000 patients


Subcutaneous concizumab prophylaxis in hemophilia A and hemophilia A/B with inhibitors: phase 2 trial results


Delivering intensive therapies to older adults with hematologic malignancies: strategies to personalize care 

These 2 reviews respectively examine the value and utility of geriatric assessment (GA) tools and discuss the role of GA in the clinical management of patients with hematologic malignancies.


How I treat Waldenström macroglobulinemia

In this How I Treat article on Waldenström macroglobulinemia, the authors present different case-based clinical scenarios and discuss available treatment options.


The microenvironmental niche in classic Hodgkin lymphoma is enriched for CTLA-4–positive T cells that are PD-1–negative 

The authors provide a topological analysis using multiplex immunofluorescence microscopy to highlight the role of CTLA-4 in the tumor microenvironment of classical Hodgkin lymphoma.

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